原则
急性中毒的救治要及时准确。在初步处理的同时要尽快设法查明中毒原因,立即终止接触毒物,阻止毒物继续侵害人体,并尽快使其排出或分解。首先将病人撤离中毒现场或去除中毒源,脱去污染的衣服,皮肤粘膜沾染的毒物应尽快冲洗,可采用清凉冷水冲洗,因热水可使血管扩张而可能保进毒物吸收,故不宜采用。冲洗要充分,否则可使毒物吸收面积扩大。口服中毒者应立即停止服用,设法促其呕吐,简单有效的办法是用手指刺激舌根部,神志清楚者可令其饮大量清水,然后刺激舌根而引起呕吐,如此反复进行,直到胃内容物全部呕吐为止。腐蚀剂中毒者可灌服牛奶、蛋清或植物油。对口服中毒者采用洗胃法是清除体内尚未被吸收的毒物的行之有效方法,将洗胃管经口腔插入胃,注意避免误入气管,先将胃内容物抽出,然后注入200-300毫升清洗液,再抽出洗液,然后再注入清洗液,如此反复,直至洗出液澄清为止。有必要时可进行手术切开洗胃,洗胃一般在服毒后6小时内效果较好。凡中毒者皆宜送医院急救。
煤气中毒
主要因吸入一氧化碳所致,可分为轻、中、重三度。轻度中毒在脱离中毒现场后,吸入新鲜空气症状迅速消失。中度中毒经及时抢救可较快清醒,预后较好。重度中毒常留有后遗症。对煤气中毒者应先将患者撤离现场,移至空气新鲜、通风良好处,若呼吸停止,宜立即进行人工呼吸。对呼吸抑制者可用呼吸兴奋剂,如尼可刹米、山梗菜碱等。同时,加强对症治疗,昏迷者应注意吸出口腔及呼吸道的分泌物,以保持呼吸道通畅。还可配合针刺太阳、列缺、人中、少商、十宣等治疗。
沥青中毒
一般分为天然沥青、石油沥青、页岩沥青和煤焦油沥青四种。以煤焦油沥青毒性最大,因直接接触受到阳光照射的沥青易产生过敏,接触了它的尘粉或烟雾易造成中毒。局部皮损主要表现为皮炎、毛囊口角化、黑头粉刺及痤疮样损害、色素沉着、赘生物等,也可出现咳嗽、胸闷、恶心等全身症状,还可见流泪、畏光、异物感及鼻咽部灼热干燥、咽炎等症状。对沥青中毒者应撤离沥青现场,避免阳光照射,对出现皮炎者可内服抗组织胺药物或静脉注射葡萄糖酸、钙维生素C及硫代硫酸钠等,局部视皮损程度对症处理,如皮炎平外搽。对毛囊性损害可外搽5%硫磺炉甘石水粉剂或乳剂。有色素沉着者可外搽3%氢醌霜或5%白降汞软膏。对赘生物可不处理或手术切除。对全身及眼、鼻、咽部症状可对症适当处理。
安眠药中毒
安眠药种类较多,以鲁米那、速可眠、氯丙嗪、安定、奋乃静等最常用,中毒主要源于服用过量或一次大量服用。安眠药对中枢神经系统有抑制作用,少量服用可催眠,过量则可致中毒。中毒者多可查及有服用安眠药病史,出现昏睡不醒,肌肉痉挛,血压下降,呼吸变浅变慢,心跳缓慢,脉搏细弱,甚至出现深昏迷和反射消失。若被吸收的药量超过常用量的15倍时可因呼吸抑制而致死。安眠药的急性中毒症状因服药量的多少、时间、空腹与否,以及个体体质差异不同而轻重各异。中毒者宜速送医院诊治,急救处理可刺激咽反射而致呕,或以1:5000高锰酸钾溶液或清水洗胃,还可以硫酸镁导泻。患者宜平卧,尽量少搬动头部。对血压下降者用去甲肾上腺素或间羟胺静脉滴注,有惊厥者可用异戊巴比妥,昏迷时给予盐酸哌醋甲酯(利他林)、印防已毒素等兴奋剂。还可加用护肝药以保护肝脏,促进代谢。中毒严重者可采用血液透析疗法。
有机磷农药中毒
农药中毒以有机磷农药中毒最为多见。在农药的生产、使用、装卸、运输、保管过程中,若不注意防护,可通过呼吸道、消化道、皮肤和粘膜等途经侵入人体而引起中毒。误服或自杀也是农药中毒的又一原因。一般分为轻、中、重度,胆碱酯酶活力降低至正常值的50-70%,出现头痛、头晕、恶心、呕吐、多汗、视力模糊、无力、胸闷、瞳孔缩小等症者为轻度中毒。中度中毒者胆碱酯酶活力降低至正常值的30-50%,还可出现肌肉颤动、轻度呼吸困难、腹痛腹泻、流涎、瞳孔明显缩小等症。胆碱酯酶活力降至正常值的30%以下,出现呼吸极度困难、肌肉震颤、瞳孔缩小如针、昏迷、大小便失禁等症者为重度中毒。一旦发生此类中毒应立即救治。迅速将病人抬至通风、空气新鲜处,脱去污染的衣物,用肥皂水和清水反复彻底清洗接触农药部位皮肤。误服者立即刺激舌根部以催吐,并用大量温水或2-5%碳酸氢钠溶液洗胃,但敌百虫中毒禁用碱性液洗胃,硫代磷酸酯类有机农药,如1606、1059、3911、乐果等中毒不可用高锰酸钾液洗胃。中毒症状明显者宜送医院救治。阿托品和特殊解毒剂的应用甚是重要,据病情轻重,阿托品1-10毫克,每10分钟-2小时一次,出现瞳孔较前散大、口干及皮肤干燥、颜面潮红、心率加快及肺部罗音消失为阿托品化征。及时应用氯磷定或解磷定。救治过程中可给氧,迅速清除呼吸道分泌物,肌注呼吸中枢兴奋药,注意保持水电解质平衡,抽搐者可水合氯醛灌肠。农药中毒可通过防护而避免,要严格遵守操作规程,严禁农药与食物混放。
急性酒精中毒
饮酒过量易造成急性酒精中毒,早期出现面红、脉快、情绪激动、语无伦次、恶心、呕吐、嗜睡等症,严重者可出现昏迷,甚至呼吸麻痹而死亡,还可高热、惊厥及脑水肿等。处理原则是禁止继续饮酒,可采用刺激舌根部以催吐,轻者饮用咖啡或浓茶可缓解症状,较重者可用温水或2%碳酸氢钠溶液洗胃。一般醉酒者经休息、饮茶即可较快恢复,中毒症状重者宜送医院诊治。对昏睡者可在洗胃后注入浓茶,出现昏迷者可肌注苯甲酸钠咖啡因0.5克或戊四氮0.1-0.2克,以及利他林、回苏林等中枢兴奋剂,呼吸抑制呈表浅缓慢呼吸衰竭时可肌注山梗菜碱10毫克或尼可刹米0.375克,必要时进行人工呼吸。对严重者可静脉注射50%葡萄糖溶液100毫升和胰岛素20单位,同时肌注维生素B6和烟酸各100毫克,以加速乙醇氧化及促进患者清醒。必要时可进行血液透析。对酒精中毒有脱水者可静脉补液。避免过量饮酒是预防本病发生的最有效方法,特别注意勿空腹大量饮酒。
食物中毒
多发生在夏秋季,多因细菌污染食物而引起的一种以急性胃肠炎为主症的疾病,最常见的为沙门氏菌类污染,以肉食为主,葡萄球菌引起中毒的食物多为乳酪制品、糖果糕点等,嗜盐菌引起中毒的食物多是海产品,肉毒杆菌引起中毒的食物多是罐头肉食制品。禁食霉腐变质的食品可预防食物中毒发生。食物中毒以呕吐和腹泻为主要表现,常在食后1小时到1天内出现恶心、剧烈呕吐、腹痛、腹泻等症,继而可出现脱水和血压下降而致休克。肉毒杆菌污染所致食物中毒病情最为严重,可出现吞咽困难、失语、复视等症。食物中毒要早救治,早期可考虑洗胃,以减少毒素的吸收,剧烈呕吐、腹痛、腹泻不止者可用硫酸阿托品注射,有脱水征兆者及时补充体液,可饮用加入少许食盐、糖的饮品,或静脉输液。可选用适宜抗菌素。肉毒杆菌食物中毒者应速送医院急救,给予抗肉毒素血清等。食物中毒早期应禁食,但不宜过长。
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